Welcome to the Baym Lab at Harvard Medical School, started in July 2017!

The lab The lab in November 2019

Antibiotic resistance is one of the defining public health threats of our time. Every time a new antibiotic has been introduced, resistance rapidly follows. We study how resistance evolves with the goal of making practical interventions that take into account, and even anticipates, pathogen evolution.

Our research ranges from basic evolutionary biology and bacteriology to analysis of clinical sequencing data to technology development.

Or, to describe what we do in Up Goer Five terms:

Very small living things that can not be killed hurt more and more people each year. People used to find many ways to kill them, but it is getting harder to find new ones that work. We study how the small things change over time to avoid being killed by us. We use this to find approaches to fighting the small things which expect these changes and change with them. We try to make approaches that can be used by doctors to keep killing the small things and to keep them from hurting people.

Our research is supported by the David and Lucile Packard Foundation, the Sloan Foundation, and the NIH NIGMS.

Lab News

July 2020:Siân and Natalia's preprint posted: Prophage-encoded phage defence proteins with cognate self-immunity

June 22, 2020:The wet lab has resumed limited activity with infection control measures.

June 2020: The lab has been awarded a Pew Biomedical Scholarship for 2020-2024! 🎉🎉🎉

June 2020: Victoria and Siân's paper, Forensic microbial system for high-resolution object provenance, is published in Science!

May 9, 2020: Ellie helps the NC Dinos (NC 다이노스) throw out the first pitch.

March 13, 2020:The wet lab closes for Covid-19.

February 2020: The lab has been awarded a Sloan Research Fellowship for 2020-2022! 🎉🎉🎉

February 2020: Karel's paper, Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing is published in Nature Microbiology!

January 2020: Kaylee joined the lab as a research associate

January 2020: Karel's preprint posted: Simplitigs as an efficient and scalable representation of de Bruijn graphs

November 2019: Elle is awarded a Rhodes Scholarship for 2020! Congratulations, Elle!

October 2019: Lucy and Jasmijn join the lab as postdocs

October 2019: Eve's Thesis wins "Best Master Thesis in Life Sciences and Technology" at EPFL! Congratulations, Eve!

September 2019: Siân and Natalia are contributing authors on The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid in PLOS Pathogens

July 2019: The lab has been awarded a MIRA/R35 Outstanding Early-Stage Investigator Award by NIH/NIGMS for 2019-2024! 🎉🎉🎉

July 2019: Michael contributes to Cell Host and Microbe's Voices on overcoming antibiotic resistance: Sustainable Stewardship Needs Evolution

July 2019: Eve presents a poster at the Microbial Population Biology Gordon Research Conference.