Studying antibiotic resistance evolution

through computation, experiment, and theory

 

Welcome to the Baym Lab at Harvard Medical School, started in July 2017!

Antibiotic resistance is one of the defining public health threats of our time. Every time a new antibiotic has been introduced, resistance rapidly follows. We study how resistance evolves with the goal of making practical interventions that take into account, and even anticipates, pathogen evolution. This relies on both experimental recapitulation of the process of resistance evolution as well as the study of genomic data from real-world infections.

More broadly, antibiotic resistance provides an excellent model system for evolution. In a sense, we as a society have been performing a directed evolution experiment in pathogens on a worldwide scale. Only now, with rapid sequencing, is the technology becoming available to understand the results.

Lab News

April 2018: Simone joined the lab

April 2018: Siân joined the lab

March 2018: Anurag started a rotation

March 2018: Victoria joined the lab

February 2018: Scott joined the lab

February 8, 2018: First preprint posted: Stronger connectivity of the resident gut microbiome lends resistance to invading bacteria

September-November 2017: Natalia rotated

September 2017: Cristina joined the lab

July 2017: The lab has started! Karel joins the lab