Welcome to the Baym Lab at Harvard Medical School, started in July 2017!
Antibiotic resistance is one of the defining public health threats of our time. Every time a new antibiotic has been introduced, resistance rapidly follows. We study how resistance evolves with the goal of making practical interventions that take into account, and even anticipates, pathogen evolution. This relies on both experimental recapitulation of the process of resistance evolution as well as the study of genomic data from real-world infections.
More broadly, antibiotic resistance provides an excellent model system for evolution. In a sense, we as a society have been performing a directed evolution experiment in pathogens on a worldwide scale. Only now, with rapid sequencing, is the technology becoming available to understand the results.