Studying microbial evolution

through computation, experiment, and theory


Welcome to the Baym Lab at Harvard Medical School, started in July 2017!

Antibiotic resistance is one of the defining public health threats of our time. Every time a new antibiotic has been introduced, resistance rapidly follows. We study how resistance evolves with the goal of making practical interventions that take into account, and even anticipates, pathogen evolution. This relies on both experimental recapitulation of the process of resistance evolution as well as the study of genomic data from real-world infections.

More broadly, antibiotic resistance provides an excellent model system for evolution. In a sense, we as a society have been performing a directed evolution experiment in pathogens on a worldwide scale. Only now, with rapid sequencing, is the technology becoming available to understand the results.

Lab News

October 2018: The lab has been awarded a 2018-2023 Packard Fellowship!

August 28, 2018: Karel's preprint posted: Lineage calling can identify antibiotic resistant clones within minutes

September 2018: Eve joined the lab as a master's student

September 2018: Michael speaks at the Southern California Microbiome Symposium

September 2018: Michael speaks at Lake Arrowhead Microbial Genomics, Siân and Karel present posters

September 2018: Cristina speaks at ISME in Germany

August 2018: Anurag joined the lab as a PhD student

July 2018: Natalia joined the lab as a PhD student

July 2018: Michael speaks at Microbial Stress Response GRC

May 2018: Isabel joined the lab as a summer undergrad

April 2018: Michael speaks at the Harvard MSI Symposium

April 2018: Simone joined the lab as a master's student

April 2018: Siân joined the lab as a postdoc

March 2018: Victoria joined the lab as a technician

February 2018: Scott joined the lab as a visiting postdoc

February 8, 2018: Cristina's preprint posted: Stronger connectivity of the resident gut microbiome lends resistance to invading bacteria

September 2017: Cristina joined the lab

August 2017: Michael speaks at the Microbial Darwinian Medicine Workshop

July 2017: The lab has started! Karel joins the lab as a joint postdoc with the Hanage Lab at HSPH